Journal article
Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation
L Loh, Z Wang, S Sant, M Koutsakos, S Jegaskanda, AJ Corbett, L Liu, DP Fairlie, J Crowe, J Rossjohn, J Xu, PC Doherty, J McCluskey, K Kedzierska
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2016
Abstract
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory cytokines. Whether MAIT cells contribute to antiviral immunity is less clear. Here we asked whether MAIT cells produce cytokines/chemokines during severe human influenza virus infection. Our analysis in patients hospitalized with avian H7N9 influenza pneumonia showed that individuals who recovered had higher numbers of CD161+ Vα7.2+ MAIT cells in peripheral blood compared with those who succumbed, suggesting a possible protective role for this lymphocyte population. To understand the mechanism underlying MAIT c..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank Andrew Brooks for insightful discussions; Ted Hansen for the alpha-MR1-26.5 blocking reagent; and Thakshila Amarasena, Sheilajen Alcantara, and Bernie McCudden for collecting blood. We thank all donors for donating blood for this study. This work was supported by National Health and Medical Research Council Program (NHMRC) Grant 1071916 (to P.C.D. and K.K.). L. Loh and S.J. were supported by an NHMRC C. J. Martin fellowship. Z.W. was supported by an NHMRC Australia-China exchange fellowship. K.K. is an NHMRC Senior Research Fellow. J.R. is an NHMRC Australia Fellow (AF50). D.P.F. is an NHMRC Senior Principal Research Fellow (1027369). S.S. is supported by a Victoria-India Doctoral Scholarship and a Melbourne International Fee Remission Scholarship (MIFRS). M.K. is supported by a Melbourne International Research Scholarship and an MIFRS.